| Date | Size | Title | Author |
| January 5, 2020 | 21 x 21 | Stressed Out | Will Nediger |
| January 12, 2020 | 21 x 21 | State of Confusion | Evan Mahnken and David Steinberg |
| January 19, 2020 | 21 x 22 | Biotechnology | Victor Barocas |
| January 26, 2020 | 21 x 21 | Food Engineering | Erik Agard |
| February 2, 2020 | 21 x 21 | Audubon Society | Brian Herrick and Christopher Adams |
| February 9, 2020 | 21 x 21 | The Emoji Movie | Brian Kulman |
| February 16, 2020 | 21 x 21 | Number Theory | Sam Ezersky |
| February 23, 2020 | 21 x 21 | Resolved | Sophia and David Maymudes |
| March 1, 2020 | 21 x 21 | Letter Dictation | Sam Trabucco |
| March 8, 2020 | 21 x 21 | What's Shaking? | Laura Taylor Kinnel |
| March 15, 2020 | 21 x 21 | Ready, Set ... Gets Low! | Nancy Stark and Will Nediger |
| March 22, 2020 | 21 x 21 | Bring Your 'A' Game | Brendan Emmett Quigley |
| March 29, 2020 | 21 x 21 | Keep the Change | Ricky Cruz |
| April 5, 2020 | 21 x 21 | Double Talk | Jim Peredo |
| April 12, 2020 | 21 x 21 | Barista Training Day | Joel Fagliano |
| April 19, 2020 | 21 x 21 | Of Course! | Jack Mowat and Jeff Chen |
| April 26, 2020 | 21 x 21 | Turn, Turn, Turn | Royce Ferguson |
| May 3, 2020 | 21 x 21 | Shifting Sounds | Ben Zimmer and Brendan Emmett Quigley |
| May 10, 2020 | 21 x 21 | Border Crossings | Adam Fromm |
| May 17, 2020 | 21 x 21 | Wide-Open Spaces | Byron Walden |
| May 24, 2020 | 21 x 21 | The Mystery of Mcguffin Manor | Andrew Chaikin |
| May 31, 2020 | 21 x 21 | What Goes Up Must Come Down | Lewis Rothlein and Jeff Chen |
| June 7, 2020 | 21 x 21 | Surplus Store | Andy Kravis |
| June 14, 2020 | 21 x 21 | Making Arrangements | Randolph Ross |
| June 21, 2020 | 21 x 21 | Animal Crossings | Byron and Harrison Walden |
| June 28, 2020 | 21 x 21 | Power-Ups | Jon Schneider and Anderson Wang |
| July 5, 2020 | 21 x 21 | To-Do List | Laura Taylor Kinnel |
| July 12, 2020 | 21 x 21 | Chores Galore | Samuel A. Donaldson |
| July 19, 2020 | 21 x 21 | Doubles Play | Wyna Liu |
| July 26, 2020 | 21 x 21 | Made-To-Order | Trenton Charlson |
| August 2, 2020 | 21 x 21 | Puzzlin' | David Levinson Wilk |
| August 9, 2020 | 21 x 21 | Craft Show | Ruth Bloomfield Margolin |
| August 16, 2020 | 21 x 21 | Alternative Cinema | Francis Heaney |
| August 23, 2020 | 21 x 21 | Musical Interlude | Barbara Lin |
| August 30, 2020 | 21 x 21 | All Aflutter | Olivia Mitra Framke |
| September 6, 2020 | 21 x 21 | Could You Repeat That Number? | David Kwong |
| September 13, 2020 | 21 x 21 | Final Offer | MaryEllen Uthlaut |
| September 20, 2020 | 22 x 21 | Word Ladders | Sam Trabucco |
| September 27, 2020 | 21 x 21 | Playing with Food | Alex Eaton-Salners |
| October 4, 2020 | 21 x 21 | You're Telling Me! | Sam Ezersky |
| October 11, 2020 | 21 x 21 | π r2 | Gary Larson |
| October 18, 2020 | 21 x 21 | Title Basin' | Miriam Estrin |
| October 25, 2020 | 21 x 21 | At the Halloween Play ... | Peter A. Collins |
| November 1, 2020 | 21 x 21 | West-Southwest | Julian Lim |
| November 8, 2020 | 21 x 21 | Wait, What? | Evan Kalish and Caitlin Reid |
| November 15, 2020 | 21 x 21 | Theme Shmeme | Caitlin Reid |
| November 22, 2020 | 21 x 21 | It All Adds Up | Alex Eaton-Salners |
| November 29, 2020 | 21 x 21 | Six-Pack | Eric Berlin |
| December 6, 2020 | 21 x 21 | Get Out of Here! | Tony Orbach |
| December 13, 2020 | 21 x 21 | Cinéma Vérité | Dan Margolis |
| December 20, 2020 | 21 x 21 | Toy Story | Randolph Ross |
| December 27, 2020 | 21 x 21 | Partnerships | Daniel Grinberg |