| Date | Size | Title | Author |
| January 3, 2010 | 21 x 21 | Antique Finish | Jeremy Newton |
| January 10, 2010 | 21 x 21 | Cross Words | Mel Rosen |
| January 17, 2010 | 21 x 21 | Subtleties | Cathy Allis |
| January 24, 2010 | 23 x 23 | Abridged Edition | David Kwong and Kevan Choset |
| January 31, 2010 | 21 x 21 | Keep an Eye on It! | Tony Orbach and Andrea Carla Michaels |
| February 7, 2010 | 23 x 23 | The Football Fan | Patrick Berry |
| February 14, 2010 | 21 x 21 | That's Amore | Matt Ginsberg and Pete Muller |
| February 21, 2010 | 21 x 21 | Words from the White House | Eric Berlin |
| February 28, 2010 | 21 x 21 | Ease-E Does It | Yaakov Bendavid |
| March 7, 2010 | 21 x 21 | Come to Order | Tony Orbach and Patrick Blindauer |
| March 14, 2010 | 23 x 23 | Book Binding | Caleb Madison |
| March 21, 2010 | 21 x 21 | Them's the Breaks | Adam Fromm |
| March 28, 2010 | 21 x 21 | What Makes It Itch? | Ed Sessa |
| April 4, 2010 | 21 x 21 | After Word | Bob Klahn |
| April 11, 2010 | 21 x 21 | Tee Time | Patrick Berry |
| April 18, 2010 | 21 x 21 | Whats-Its | Randolph Ross |
| April 25, 2010 | 21 x 21 | Monumental Achievement | Elizabeth C. Gorski |
| May 2, 2010 | 21 x 21 | Fix-A-Tion | Kelsey Blakley |
| May 9, 2010 | 21 x 21 | Ms. Conceptions | Elizabeth C. Gorski |
| May 16, 2010 | 21 x 21 | Double Crossers | Matt Ginsberg |
| May 23, 2010 | 21 x 21 | Flip-Flops | Yaakov Bendavid |
| May 30, 2010 | 21 x 21 | Full Circle | Eric Berlin |
| June 6, 2010 | 21 x 21 | Typecasting | Daniel A. Finan |
| June 13, 2010 | 21 x 21 | Flag Day | Francis Heaney |
| June 20, 2010 | 21 x 21 | Publishing Trade | Todd Gross and Ashish Vengsarkar |
| June 27, 2010 | 21 x 21 | To Thine Own Self be True | Michael J. Doran |
| July 4, 2010 | 21 x 21 | Making Ends Meet | Patrick Blindauer and Tony Orbach |
| July 11, 2010 | 21 x 21 | As Elmer Fudd Would Say ... | Ed Sessa |
| July 18, 2010 | 21 x 21 | Critical Periods | Robert W. Harris |
| July 25, 2010 | 21 x 21 | Up Starts | Alan Arbesfeld |
| August 1, 2010 | 21 x 21 | Play Bargaining | Brendan Emmett Quigley |
| August 8, 2010 | 21 x 21 | 3 X 8 | Pam Klawitter |
| August 15, 2010 | 21 x 21 | Is There an Echo in Here? | Daniel C. Bryant |
| August 22, 2010 | 21 x 21 | Film No-R | Patrick Berry |
| August 29, 2010 | 21 x 21 | Going for a Run | Derek Bowman |
| September 5, 2010 | 21 x 21 | Turning Back | Will Nediger |
| September 12, 2010 | 21 x 21 | It's Going to Cost You | Paula Gamache |
| September 19, 2010 | 21 x 21 | Musical Play | Kevin G. Der |
| September 26, 2010 | 21 x 21 | Location, Location, Location | Pamela Amick Klawitter |
| October 3, 2010 | 21 x 21 | Can I Change Places? | Daniel A. Finan |
| October 10, 2010 | 21 x 21 | Drivers' Translations | Patrick Merrell |
| October 17, 2010 | 21 x 21 | Figure of Speech | Patrick Blindauer |
| October 24, 2010 | 21 x 21 | Risky Business | Brendan Emmett Quigley |
| October 31, 2010 | 21 x 21 | Fangs for the Memory | Elizabeth C. Gorski |
| November 7, 2010 | 21 x 21 | Leading Articles | Will Nediger |
| November 14, 2010 | 21 x 21 | Doubleheaders | Patrick Berry |
| November 21, 2010 | 21 x 21 | Having Aspirations | Clive Probert |
| November 28, 2010 | 23 x 23 | A Shining Moment | Jeremy Newton |
| December 5, 2010 | 21 x 21 | On a Roll | Ben Pall |
| December 12, 2010 | 21 x 21 | The Wish | Karen Young Bonin |
| December 19, 2010 | 23 x 23 | Hope for Clear Skies | Kevin G. Der |
| December 26, 2010 | 21 x 21 | Hey, Mister! | Darin McDaniel |