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BIOTECHNOLOGY

New York Times, Sunday, January 19, 2020

Author:
Victor Barocas
Editor:
Will Shortz
Blog:
2-Down : Anon
TotalDebutLatestCollabs
202/9/20112/6/202410
SunMonTueWedThuFriSat
9124301
CircleScrabDebutFresh
61.6014650%
Victor Barocas

This puzzle:

Rows: 21, Columns: 22 Words: 141, Blocks: 80 Missing: {QZ} This is puzzle # 14 for Mr. Barocas. Sunday freshness: 82%
Will Shortz notes:
Victor Barocas is a professor of biomedical engineering at the University of Minnesota with more than 100 published works in the field. Given his profession, the genesis of this puzzle (spelled out ... read more
Victor Barocas notes:
My initial idea for this puzzle was MAILMERGE, and I even got to the point of filling a grid with things like AIRMAIL, CHAINMAIL, etc., merging them diagonally (similar to the GENEs in the final ... read more
Jeff Chen notes:
I love it when a constructor's personality or interests shine through in a puzzle, and that's certainly the case today. I enjoyed the biomedical engineering classes I took in college and grad ... read more
Jim Horne notes:

Eugène Ionesco is well known to theatre people. His absurdist play The Bald Soprano (La Cantatrice chauve) holds a peculiar record. It started a run at a theatre in Paris in 1957. It's still there. Tickets available here.

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© 2020, The New York Times1/19/20 ( No. 25,639 )
Across
1
Homeowner's action, for short : REFI
5
Things blockers block : ADS
8
1979 film inspired by Janis Joplin's life : THEROSE
15
Indistinct shape : BLOB
19
Receptionist on "The Office" : ERIN
20
Be bothered by : MIND
22
Island nation west of Fiji : VANUATU
23
Possible consequence of default, in brief : REPO
24
Wildflower with spiky, purplish blooms : HEDGENETTLE
25
Secure : MOOR
26
Ruling family of Edward I : PLANTAGENETS
27
Finished : OVER
28
Adam's ___ (water) : ALE
29
Hole in one's head : EARCANAL
31
Humpty Dumpty, e.g. : EGG
32
"Dallas" family name : EWING
33
The Anne of "Anne of the Thousand Days" : BOLEYN
35
Feverish : AFIRE
36
Put back on : RERAN
38
Insinuating : SNIDE
40
James who won an Emmy two years in a row for the same role on different shows : SPADER
45
Ignorant person, in slang : GOOBER
47
Security system array : SENSORS
49
Total : ENTIRE
51
Angered by : MADAT
53
Ancient monuments : STELES
54
Gaston ___, "The Phantom of the Opera" novelist : LEROUX
55
Latte choice, informally : CAF
58
The "she" in the lyric "She would merengue and do the cha-cha" : LOLA
59
W.W. I French biplane : SPAD
60
Capital of Albania : TIRANE
61
Like much of Iowa : RURAL
63
1980 Olympic hockey champs : USA
66
Up : ARISEN
68
Shark fighters : JETS
70
"Believe ___ not!" : ITOR
71
Biological manipulation suggested four times by this puzzle : GENESPLICING
74
First African-American Davis Cup player : ASHE
75
Beethoven's birthplace : BONN
76
Comprehension : UPTAKE
77
Tender spot? : ATM
78
Like the sun god Inti : INCAN
79
Some liturgical vestments : STOLES
81
___ de Triomphe : LARC
83
It's down in the dumps : ODOR
86
First National Leaguer to hit 500 home runs : OTT
87
Fall color providers : MAPLES
88
Some instant coffees : SANKAS
90
Cheyenne Mountain org. : NORAD
92
Stays out of : EVADES
93
Closes in a thin membrane : ENCYSTS
95
Disappointing response to an application : DENIED
98
Remarkable ability of a starfish : REGENERATION
99
Use a rototiller on, say : AERATE
101
Lack of variation : HOMOGENEITY
103
"ER" actress Laura : INNES
105
Turn out : ENDUP
106
Service with more than 1.5 billion users : GMAIL
107
Home of the Latino Walk of Fame, informally : EASTLA
108
Composer of the "London" symphonies : HAYDN
111
Big e-cigarette brand : BLU
113
Anti-athlete's foot brand : LOTRIMIN
115
Good for leaving handprints in : WET
116
State without reservations : AVOW
119
Provider of child support? : KNEE
121
Polynesian carving : TIKI
122
Dreamer : WANNABE
123
Half in advance? : SEMI
124
Unique individual : ONER
125
Starting point : EDEN
126
Broadway's "___ Todd" : SWEENEY
127
"Hamilton" Tony nominee Phillipa ___ : SOO
128
Loch ___, site of Urquhart Castle : NESS
Down
1
Goes through physical therapy : REHABS
2
Anon : ERELONG
3
Beethoven's only opera : FIDELIO
4
As a rule : INGENERAL
5
City that ancient Greeks called Philadelphia : AMMAN
6
Christian with a big house : DIOR
7
Winter vehicle : SNOCAT
8
Mike and Carol Brady, e.g. : TVPARENTS
9
Berry receiving much attention in the 2000s : HALLE
10
Bambi's aunt : ENA
11
Bit of ancient script : RUNE
12
Ingredient in some health food supplements : OATGRASS
13
Not occurring naturally : STAGED
14
Romanian-born writer once in the French Academy : EUGENEIONESCO
15
Cook on the outside : BROWN
16
Tribe of Moses and Aaron : LEVI
17
Available to the public : OPEN
18
Wimbledon champ, 1976-80 : BORG
21
First takes : DRAFTS
29
Gag item floating in Halloween punch : EYEBALL
30
Brother on "Frasier" : NILES
32
Breadwinner : EARNER
34
Ancient Dead Sea land : EDOM
37
Woozy : REELING
40
Rooms with views : SOLARIA
41
Forecast : PREDICT
43
Phrase of agreement : TRUETHAT
44
Subject for Kinsey : SEX
46
Olden Tokyo : EDO
48
Flower part : SEPAL
50
Roman emperor before Hadrian : TRAJAN
52
"Nyah, nyah!," e.g. : TAUNT
55
Nursery sight : CRIB
56
Insurance for the crash-prone : AUTOSAVE
57
Big story : FRONTPAGENEWS
60
Start of a countdown : TEN
62
Composer Schoenberg : ARNOLD
64
Repair material : SEALANT
65
Skeptically : ASKANCE
67
Apostle called "the Zealot" : SIMON
69
Launched : SENT
71
Didn't know but said something anyway : GUESSED
72
Midlength records, for short : EPS
73
Full of spirit : PERKY
78
From Shiraz or Tabriz : IRANIAN
80
Country star Womack : LEEANN
82
Greenbacks : CASHMONEY
84
1990s-2000s compact car : DODGENEON
85
Smelter's supply : ORE
87
Locale for un capitaine : MER
88
It doesn't need land to land : SEAPLANE
89
Sometimes-white animal : STOAT
91
Rackets : DINS
94
Smiles smugly : SMIRKS
96
Twist together : ENTWINE
97
X's : DELETES
100
Chafe : RUBRAW
102
QB protection squads : OLINES
104
Companions of Dionysus : SATYRS
105
John Wilkes Booth's actor brother : EDWIN
106
Wikipedia's logo : GLOBE
107
Refrain from nursery singing : EIEIO
108
"In time we ___ that which we often fear": Shak. : HATE
109
Devoted : AVID
110
Make into a couple : YOKE
112
Magazine with the motto "Cure ignorance" : UTNE
114
Staff note : MEMO
118
First name in spy literature : IAN

Answer summary:
10 unique to this puzzle, 2 debuted here and reused later, 2 unique to Modern Era but used previously.

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